Deutsch

 

 

Center for Molecular Biology of Inflammation - ZMBE

Mol. Virology

 

Institute-associated Research Group -

Virus Endocytosis

 

Start page

Research

Publications

Staff

 

Mol. Virology start page

 

Choose a ZMBE institute

 

Institute-associated Emmy-Noether Research Group -

Virus Endocytosis

 

Start page

Overview of a typical endocytic entry route of an animal virus into host cells (taken from Marsh and Helenius, Cell, 124, 729-40)

 

Our group studies the interactions that occur between incoming animal viruses and their host cells during early infection. Viruses are simple, obligatory, intracellular parasites that depend on the host cell for most of the steps in the replication cycle. This is particularly critical during cell entry, which occurs usually by endocytic uptake and intracellular vesicle transport to deliver the genome to the site of replication. For this, viruses hijack cellular processes for signaling, membrane trafficking, intra- and inter-cellular transport, nuclear import and export, and molecular sorting. Thus, viruses are also valuable tools to analyze endocytic membrane transport phenomena. Accordingly, our research focusses as much on the understanding of the basic cell biology of endocytosis as it does help to fight viral diseases.

 

Using cellular and molecular techniques in combination with video microsopy in live cells, and systems biology approaches, we investigate how virus particles bind to cells, how they are internalized by endocytosis, and how they are transported to various endosomal organelles. We are also analyzing how the viral genome and accessory proteins escape into the cytosol from these organelles, and how they enter into the nucleoplasm.

 

picture

 

 

 

Dr. Jens Schwammborn

Contact address

 

Mario Schelhaas, PhD, MSc - Principal Investigator

 

Emmy Noether Group:
Novel Endocytic Pathways as defined by Virus Entry
ZMBE - Institutes for Medical Biochemistry and Molecular Virology
Von-Esmarch-Str. 56
D-48149 Münster

 

phone: +49-(0)251-83 57182 (office)
+49-(0)251-83 52223/4 (labs)
fax: +49-(0)251-83 57184
email: schelhaas at uni-muenster.de