Center for Molecular Biology of Inflammation

Inst. of Molecular Virology - Publications

2010

Ehrhardt, C., Seyer, R., Hrincius, E.R., Eierhoff, T., Wolff, T., and Ludwig, S.

Interplay between influenza A virus and the innate immune signaling.

Microbes Infect. 12(1):81-87 (2010)

2009

Hrincius, E.R., Wixler, V., Wolff, T., Wagner, R., Ludwig, S., and Ehrhardt, C.

CRK adaptor protein expression is required for efficient replication of avian influenza A viruses and controls JNK mediated apoptotic responses.

Cell. Microbiol., Epub ahead of print (Dec 23rd) (2009)

Ma, W., Brenner, D., Wang, Z., Dauber, B., Ehrhardt, C., Högner, K., Herold, S., Ludwig, S., Wolff, T., Yu, K., Richt, JA., Planz, O., Pleschka, S.

The NS-segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency, cell tropism and host range of an H7N1 HPAIV.

J. Virol. doi: 10.1128 /JVI.01668-09 (2009)

Bender, H., Wiesinger, M. Y., Nordhoff, C.,Schoenherr, C., Haan, C., Ludwig, S., Weiskirchen, R., Kato, N., Heinrich, P.C., Haan, S.

Interleukin-27 displays inerferon γ-like functions in human hepatoma cells and hepatocytes.

Hepatology 50, 585-591 (2009)

Pauli, E.K., Schmolke, M., Hofmann, H., Ehrhardt C., Flory E., Münk C., and Ludwig S.

High level expression of the anti-retroviral protein APOBEC3G is induced by influenza A virus but does not confer antiviral activity.

Retrovirology 6:38 (2009)

Eierhoff, T., Ludwig, S., Ehrhardt, C.

The influenza A virus matrix protein as a marker to monitor initial virus internalisation.

Biol Chem. 390,509-515 (2009)

Mitzner, D., Mazur, I., Studtrucker, N., Anhlan, D., Wixler, L., Wissing, J., Jänsch, L., Bruns, K., Sharma, A., Wray, V., Henklein, P., Ludwig, S.*, and Schubert, U.*

Phosphorylation of the influenza A virus PB1-F2 protein by PKC is required for efficient virus propagation.

Cell. Microbiol. 11, 1502-1516, * shared seniorauthorship (2009)

Schmolke, M., Viemann, D., Roth, J., and Ludwig, S.

Essential Impact of NF-κB Signaling on the H5N1 Influenza A Virus Induced Transcriptome.

J. Immunol. 183, 5180-5189 (2009)

Ehrhardt, C., Seyer, R., Hrincius, ER., Eierhoff, T., Wolff, T., Ludwig, S.

Interplay between influenza A virus and the innate immune signaling. (Review)

Microbes Infect., Epub ahead of print (Sep 25) (2009)

Ludwig, S., Wolff, T.

Influenza A virus TRIMs the type I interferon response. (Review)

Cell Host Microbe 8, 5420-5421 (2009)

Spiering, D., Schmolke, M., Ohnesorge, N., Schmidt, M., Goebeler, M., Wegener, J., Wixler, V., Ludwig, S.

MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover.

J. Biol. Chem. 284, 24972-24980 (2009)

Ehrhardt, C and Ludwig, S.

A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway. (Review)

Cell. Microbiol. 390, 509-15 (2009)

Ludwig, S

Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy. (Review)

J. Antimicrob. Chemother. 64, 1-4 (2009)

Wolff, T. and Ludwig, S.

Influenza Viruses control the vertebrate TypeΙ IFN system: Factors, Mechanisms and Consequences. (Review)

J. Interferon Cytokine Res. 284, 24972-24980 (2009)

2008

Mazur, I., Anhlan, D., Mitzner, D., Wixler, L., Schubert, U., and Ludwig, S.

The influenza A virus PB1-F2 protein regulates viral polymerase activity by interaction with the PB1 protein.

Cell. Microbiol., 10, 1140–1152 (2008)

Park, J., Will, C., Martin, B., Gullotti, L., Friedrichs, N., Buettner, R., Schneider, H., Ludwig, S., and Wixler, V.

Deficiency in the LIM-only protein FHL2 impairs assembly of extracellular matrix proteins.

FASEB J, 22, 2508-2520 (2008)

Feld, M., Shpacovitch, V. M., Ehrhardt, C., Kerkhoff, C., Hollenberg, M.D., Vergnolle, N., Ludwig, S., and Steinhoff, M.

Agonists of Proteinase-activated Receptor-2 enhance IFNγ-inducible effects on human monocytes: role in influenza A infection.

J Immunol 180, 6903-6910 (2008)

Kramer, A., Liashkovich, I., Oberleithner, H., Ludwig, S., Mazur, I, and Shahin, V.

Apoptosis leads to a degradation of vital components of active nuclear transport and a dissociation of the nuclear lamina.

Proc. Natl. Acad. Sci. U.S.A., 105, 11236-11241 (2008)

Bode G., Lüken A., Kerkhoff C., Roth J., Ludwig S., and Nacken W.

Interaction between S100A8/A9 and annexin A6 is involved in the calcium induced cell surface exposition of S100A8/A9.

J. Biol. Chem., 14 283, 31776-31784 (2008)

Pauli, E.K., Schmolke, M., Viemann, D, Roth, J., Bode, J.G., and Ludwig, S.

Influenza A virus inhibits type I IFN signaling via NF-κB dependent induction of SOCS-3 expression.

PLOS Pathogens, 4(11):e1000196. (2008)

Ludwig, S., and Planz, O.

Influenza viruses and the NF-κB signaling pathway – towards a novel concept of antiviral therapy. (Review)

Biol Chem, 389, 1307-1132 (2008)

Ludwig, S.

Highlight - viruses and signaling (Editorial)

Biol Chem, 389, 1251 (2008)

2007

Knoblauch, A., Will, C., Goncharenko, G., Ludwig, S., and Wixler, V.

Binding of Mss4 protein to alpha-integrin subunits regulates MMP activation and fibronectin remodeling.

FASEB J 21, 497-510 (2007)

Ehrhardt, C., Wolff, T., Pleschka, S., Planz, O., Beermann, W., Bode, J.G., Schmolke, M., and Ludwig, S.

The influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses,

J. Virol. , 81, 3058-3067 (2007)

Viemann, D., Schmidt, M., Tenbrock, K., Schmid, S., Müller, V., Klimmek, K., Ludwig, S., Roth, J., and Goebeler M.

Nickel compounds trigger a unique proinflammatory and proangiogenic/proliferative gene expression pattern mediated by independent activation of IKK2/NF-kappaB and HIF-1a pathways.

J. Immunol. 178, 3198-3207 (2007)

Ehlting, C., Lai, W.S., Schaper, F., Brenndörfer, E.D., Matthes, R.J., Heinrich, P.C., Ludwig, S., Blackshear, P.J., Gaestel, M., Häussinger, D., Bode, J.G.

Regulation of suppressor of cytokine signaling 3 mRNA expression by TNF-alpha involves activation of the MKK6/p38MAPK/MK-2 cascade.

J. Immunol. 178, 2813-2826 (2007)

Mazur, I, Wurzer, W.J., Ehrhardt, C., Pleschka, S., Puthavathana, P., Silberzahn, T., Wolff, T., Planz, O., Ludwig, S.

Acetylsalicylic acid (ASA) blocks influenza virus popagation via its NF-kappaB inhbiting activity.

Cell. Microbiol. 9,1683-1694 (2007)

Adler, H.A., Kubsch, S., Graulich, E., Ludwig, S., Knop, J., and Steinbrink, K.

Activation of MAP kinase p38 is critical for cell cycle controlled suppressor activity of regulatory T cells.

Blood 109, 4351-4359 (2007)

Albrecht, U., Yang, X., Asselta, R., Keitel, V., Tenchini, M.L., Ludwig, S., Heinrich, P.C., Häussinger, D., Schaper, F., Bode, G.

Activation of NF-kappaB by IL-1beta blocks IL-6-induced sustained STAT3 activation and STAT3-dependent gene expression of the human gamma-fibrinogen gene.

Cell. Signal. 9,1866-78 (2007)

Droebner, K., Ehrhardt, C., Pötter, A., Ludwig, S., and Planz, O.

CYSTUS052, a polyphenol rich plant extract exerts anti influenza virus activity in mice.

Antiviral Res. 76, 1-10 (2007)

Ehrhardt, C., Hrincius, E.R., Mazur, I., Korte, V., Pötter, A., Dreschers, S., Droebner, K., Schmolke, M., Planz, O., and Ludwig, S.

A polyphenol rich plant extract, CYSTUS052, exerts anti influenza virus activity in cell culture without toxic side effects or the tendency to induce viral resistance.

Antiviral Res. 76, 38-47 (2007)

Vogl, T., Tenbrock, K., Ludwig, S., Leukert, N., Ehrhardt, C., van Zoelen, M., Nacken, W., Foell, D., van der Poll, T., Sorg, C., and Roth, J.

MRP8 and MRP14 are endogenous activators of toll-like receptor 4 promoting lethal endotoxin-induced shock.

Nat. Med. 3, 1042-1049 (2007)

Ehrhardt, C., Wolff, T., and Ludwig, S.

Activation of phosphatidyl-inositol-3-kinase (PI3K) signaling by the non-structural NS1 protein is not conserved among type A and B influenza viruses.

J. Virol., 81, 12097-12100 (2007)

Müller, V., Viemann, D., Endres, N., Ludwig, S., Leverkus, M., Roth, J., and Goebeler M.

Candida albicans triggers activation of distinct signaling pathways to establish a proinflammatory gene expression program in primary human endothelial cells.

J. Immunol., In press (2007)

Ludwig, S.

Influenza viruses and MAP kinase cascades – Novel targets for antiviral therapy? (Review)

Signal Transduction 7, 81-88 (2007)

Ludwig, S.

Exploited defense – how influenza virus takes advantage of antiviral signaling responses (Review)

Future Virology 2, 91-100 (2007)

2006

Ehrhardt C., Marjuki, H., Wolff, T., Nürnberg, B., Planz, O., Pleschka S., and Ludwig, S.

Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defense.

Cell. Microbiol., 8,1336-1348 (2006)

Marjuki, H., Alam, M.I., Ehrhardt, C., Wagner, R., Planz, O., Klenk, H.D., Ludwig S. and Pleschka, S.

Lipid raft association of influenza A virus hemagglutinin triggers signaling and nuclear export of the viral genome.

J. Biol. Chem., 281, 16707-15 (2006)

Ehrhardt, C., Schmolke, M., Matzke, A., Knoblauch, A., Will, C., Wixler, V., and Ludwig, S.

Polyethylenimine, a cost-effective transfection reagent.

Signal Transduction, 6, 179-184 (2006)

Ludwig S., Pleschka S., Planz, O. and Wolff, T.

Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells. (Review)

Cell. Microbiol. 8,375–386 (2006)

2005

Voncken, J.W., H. Niessen, B. Neufeld, U. Rennefahrt, V. Dahlmans, N. Kubben, B. Holzer, Ludwig, S., and Rapp, U.R.

MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1.

J Biol Chem, 280, 5178-5187 (2005)

Bourteele, S., Oesterle K., Pleschka, S., Unterstab, G., Ehrhardt, C., Wolff, T., Ludwig, S. and Planz, O.

Constitutive activation of the transcription factor NF-kappaB results in impaired Borna disease virus replication.

J. Virol., 79, 6043-6051 (2005)

Unterstab, G., Ludwig S., Anton, A., Planz, O., Dauber, B., Knappmann, D., Heins, G. and Wolff, T.

Viral targeting of the Interferon-beta inducing TANK-binding Kinase-1.

Proc Natl Acad Sci USA, 102, 13640-13645 (2005)

2004

Viemann D, Goebeler M, Schmid S, Klimmek K, Sorg C, Ludwig S, Roth J.
Transcriptional profiling of IKK2/nuclear factor-kappaB and p38 MAP kinase dependent gene expression in tumor necrosis factor-stimulated primary human endothelial cells.
Blood 103, 3365-3373 (2004).

Ludwig S, Wolff T, Ehrhardt C, Wurzer WJ, Reinhardt J, Planz O, Pleschka S.
MEK-inhibition impairs influenza B virus pragation without emergence of resistant virus variants.
FEBS Lett. 561, 37-43 (2004).

Ehrhardt C, Kardinal C, Wolff T, Wurzer WJ, von Eichel-Streiber C, Pleschka S, Planz O, Ludwig S.
Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon regulatory factor-3 (IRF-3).
FEBS Lett. 567, 230-238 (2004).

Krull M, Kramp, J, Petrov, T, Klucken, AC, Hocke AC, Walter C, Schmeck B, Seybold J, Maass M, Ludwig S, Kuipers, JG, Suttorp N, and Hippenstiel S.
Differences in cell activation by Chlamydophila pneumoniae and Chlamydia trachomatis infection in human endothelial cells.
Infect Immun. 72, 6615-6621. (2004)

Ölschläger V, Pleschka S, Fischer T, Wurzer W, Stitz L, Rapp UR, Ludwig S , and Planz O.
Increased mortality after influenza A virus infection of mice expressing active Raf kinase in the lung.
Oncogene 23, 6639-6646 (2004).

Vogl, T., Ludwig, S., Goebeler, M., Strey, A., Thorey, I.S., Reichelt, R., Foell, D., Gerke, V., Manitz, M.P., Nacken, W., Werner, S., Sorg, C., and Roth, J.

MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes.

Blood, 104, 4260-4268 (2004)

Wurzer WJ, Ehrhardt C, Pleschka S, Berberich-Siebelt F, Walczak H, Planz O, and Ludwig S .
NF-kappaB dependent induction of TRAIL and Fas/FasL is crucial for efficient influenza virus propagation.
J. Biol. Chem. 279, 30931-30937 (2004).

Zakowski V, Keramas G, Kilian K, Rapp UR, and Ludwig S .
Mitogen-activated 3p kinase (3pK) is active in the nucleus.
Exp. Cell Res. 299, 101-109 (2004).

Yang XP, Albrecht U, Zakowski V, Häussinger D, Heinrich PC, Ludwig S , Bode JG and Schaper F.
SOCS-3 expression in response to IL-6 is regulated by IL-1ß positively and negatively through distinct NF-kappaB dependent and independent pathways.
J. Biol. Chem., 279, 45279-45289, (2004).

Ludwig, S.

Influenza-Virus-induzierte Signalkaskaden – Ziel für eine antivirale Therapie? (Review)

Biospektrum, 10, 517-519 (2004)

2003

Bode JG, Ludwig S , Ehrhardt C, Erhardt A, Ruhl M, Schaper F, Heinrich PC, Häussinger D.
Interferon-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling (SOCS)-3.
FASEB J. 17, 488-90 (2003).

Ludwig S , Pleschka S, Planz O, Wolff T.
Influenza virus induced signalling cascades: targets for antiviral therapy?
Trends Mol. Med. 9, 46-52 (2003).

Planz O, Pleschka S, Ehrhardt C, Österle K, Siebelt-Berberich F, Stitz L, Ludwig S .
The Borna disease virus nucleoprotein interacts with the Cdc2/cyclinB1 complex.
J. Virol. 77, 11186-11192 (2003).

Scheller C, Sopper S, Koutsilieri E, Ludwig S , Ter Meulen V, and Jassoy C.
Caspase inhibitors as a supplement in immune activation therapies to achieve eradication of HIV in its latent reservoirs.
Ann. N.Y. Acad. Sci 1010, 209-212 (2003).

Wurzer WJ, Planz O, Ehrhardt C, Giner M, Silberzahn T, Pleschka S, Ludwig S .
Caspase-3 activation is essential for efficient influenza A virus propagation.
EMBO J. 22, 2717-2728 (2003).

2002

Scheller C, Sopper S, Chen P, Flory E, Koutsilieri E, Racek T, Ludwig S , ter Meulen V, Jassoy C.
Caspase inhibition activates HIV in latently infected cells: role of TNF-R1 and CD95.
J. Biol. Chem. 277, 15459-15464 (2002).

Kunz M, Bloss G, Gillitzer R, Goebeler M, Gross G, Rapp UR, Ludwig S.
Role of NF-?B and SP-1 in the regulation of monocyte chemoattractant protein (MCP)-1 in melanoma cells under hypoxia/reoxygenation.
Biochem. J. 366, 299-306 (2002).

Scheller C, Sopper S, Ehrhardt C, Flory E, Chen P., Koutsilieri E, Ludwig S , ter Meulen V, Jassoy C.
Caspase inhibitors induce a switch from apoptotic to proinflammatory signaling in CD95-stimulated T lymphocytes.
Euro. J. Immunol. 32, 2471-2480 (2002).

Ludwig S , Wang X, Ehrhardt C, Zheng H, Donelan N, Planz O, Pleschka S, Garcia-Sastre A, Heins G, Wolff T.
The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase (JNK) and AP-1 transcription factors.
J. Virol. 76, 11166-11171 (2002).

2001

Goebeler M, Gilitzer R, Kilian K, Utzel K, Bröcker EB, Rapp UR, Ludwig S .
Multiple signaling pathways regulate NF-kappaB dependent transcription of the MCP-1 gene in primary endothelial cells.
Blood 97, 46-55 (2001).

Pleschka S, Wolff T, Ehrhardt C, Hobom G, Planz O, Rapp UR, Ludwig S .
Influenza virus replication is impaired by inhibition of the Raf/MEK/ERK signaling cascade.
Nature Cell Biol. 3, 301-305 (2001).

Ludwig S , Ehrhardt C, Neumeier E, Kracht M, Rapp UR, Pleschka S.
Influenza virus induced AP-1 dependent gene expression requires activation of the Jun-N-terminal kinase (JNK) cascade.
J. Biol. Chem. 276, 10990-10998 (2001).

Kunz M, Ibrahim S, Koczan D, Thiesen H-J, Köhler HJ, Ludwig S , Rapp UR, Bröcker E-B, van Muijen G, Flory E, Gross G.
Activation of c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) is critical for hypoxia-induced apoptosis of human malignant melanoma.
Cell Growth Differ. 12, 137-145 (2001).

Planz O, Pleschka S, Ludwig S .
The MEK specific inhibitor U0126 blocks spread of Borna Disease Virus in infected cultured cells.
J. Virol. 10, 4871-4877 (2001).

Fischer TA, Ludwig S , Flory E, Gambaryan S, Khrisna S, Pfeffer MA, Kelly RA, Pfeffer JM.
Activation of cardiac c-Jun NH2-terminal kinases and p38-mitogen-activated protein kinases with abrupt changes in hemodynamic load.
Hypertension 37, 1222-1228 (2001).

Labunski S, Posern G, Ludwig S , Bröcker EB, Kunz M.
TNF promoter polymorphism in erythema nofodum.
Acta Derm Venerol 81, 18-21 (2001).

Denk A, Goebeler M, Schmid S, Berberich I, Lindemann D, Ludwig S , Wirth T.
Activation of NF-kappaB via the IkappaB-kinase complex is both essential and sufficient for proinflammatory gene expression in primary endothelial cells.
J. Biol. Chem. 276, 28451-28458 (2001).

Roth J, Goebeler M, Ludwig S , Wagner L, Kilian K, Sorg C, Harms E, Schulze-Osthoff K, Koch H-G.
Homocysteine inhibits TNF mediated activation of endothelium via modulation of NF-kappaB activity.
Biochem. Biophys. Acta 1540, 154-165 (2001).

Dinev D, Jordan B, Neufeld B, Lee JD, Lindemann D, Rapp UR, Ludwig S .
Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells.
EMBO reports 2, 829-834 (2001).

Schmidt M, Gillitzer R, Toksoy A, Bröcker EB, Rapp UR, Paus R, Roth J, Ludwig S , Goebeler M.
Selective expression of calcium binding-proteins S100A8 and S100A9 at distinct sites of hair follicles.
J. Invest. Dermatol. 117, 748-750 (2001).

Terstegen L, Gatsios P, Ludwig S , Pleschka S, Jahnen-Dechent W, Heinrich PC, Graeve L.
The vesicular stomatitis virus M protein inhibits IL-6-induced STAT activation.
J. Immunol. 167, 5209-5216 (2001).

Bode J, Ludwig S , Correia Freitas CA, Schaper F, Ruhl M, Melmed S, Heinrich PC, Häussinger D.
The MKK6/p38 mitogen activated protein kinase pathway is involved in IL-6 induced autoregulatory negative feedback inhibition via SOCS-3.
Biol. Chem. 382, 1447-1453 (2001).

Jordan BWM, Dinev D, Troppmair J, Götz R, Wixler L, Sendtner M, Ludwig S , Rapp UR.
NRAGE is an inducible IAP-interacting protein that augments cell death.
J. Biol. Chem. 276, 39985-39989 (2001).

2000

Flory E, Kunz M, Scheller C, Stauber R, Jassoy C, Rapp UR, Ludwig S .
Influenza virus induced NF-kappaB dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activation of IkappaB-kinase.
J. Biol. Chem. 275, 8307-8314 (2000).

Hippenstiel S, Soeth S, Kellas B, Fuhrman O, Seybold J, Krüll M, v. Eichel Streiber C, Goebeler M, Ludwig S, Suttorp N.
Rho proteins and p38 MAPK pathway are important mediators for LPS-induced IL-8 synthesis in human endothelial cells.
Blood 95, 3044-3051 (2000).

Chen P, flory E, Avots A, Jordan BWM, Kirchhoff F, Ludwig S , Rapp UR.
Transactivation of naturally occuring HIV-LTRs by the JNK signaling pathway: the MFNLP sequence introduces a novel binding site for AP-1 factors.
J. Biol. Chem. 275, 20382-20390 (2000).

Neufeld B, Große-Wilde A, Hoffmeyer A, Jordan BWM, Chen P, Dinev D, Ludwig S , Rapp UR.
The serine/threonine kinases 3pK and MAPKAP-K2 interact with the basic HLH-transcription factor E47 and repress its transcriptional activity.
J. Biol. Chem. 275, 20239-20242 (2000).

Schmidt M, Goebeler M, Posern G, Feller SM, Bröcker EB, Seitz C, Rapp UR, Ludwig S.
Ras-indepedent activation of the Raf/MEK/ERK pathway upon calcium-induced differentiation of keratinocytes.
J. Biol. Chem. 275, 41011-41017 (2000).

1999

Ludwig S , Pleschka S, Wolff T.
A fatal relationship - Influenza virus interactions with the host cell (invited review).
Viral Immunol. 12, 175-196 (1999).

New L, Zhao M, Li Y, Bassett WW, Fong Y, Ludwig S , Padova FD, Gram H, Han J.
Cloning and characterization of RLPK, a novel RSK-related protein kinase.
J Biol Chem 274, 1026-1032 (1999).

Hoffmeyer A, Große-Wilde A, Flory E, Neufeld B, Kunz M, Rapp UR, Ludwig S .
Different mitogen-activated protein kinase signaling pathways cooperate to regulate tumor necrosis factor alpha gene expression in T lympho-cytes.
J Biol Chem 274, 4319-4327 (1999).

Goebeler M, Kilian K, Gilitzer R, Kunz M, Yoshimura T, Bröcker EB, Rapp UR, Ludwig S .
The MKK6/p38 stress kinase cascade is critical for TNF induced expression of monocyte chemoattractant protein-1 in endothelial cells.
Blood 93, 857-865 (1999).

Bode JG, Gatsios P, Ludwig S , Rapp UR, Häussinger D, Heinrich PC, Graeve L.
The mitogen activated protein (MAP) kinase p38 and its upstream activator MAP kinase (MKK6) are involved in the activation of signal transducer and activator of transcription by hyperosmolarity.
J Biol Chem 274, 30222-30227 (1999).

1998

Ludwig S , Hoffmeyer A, Goebeler M, Häfner H, Kilian K, Neufeld B, Han J, Rapp UR.
The stress inducer arsenite activates mitogen activated protein kinases ERK 1/2 via a MKK6/p38RK dependent pathway.
J. Biol. Chem. 273, 1917-1922 (1998).

Invited Reviews (peer reviewed)

Ludwig, S., and Rapp, U. R. (1995).

Cascading towards vascular disorder gene therapy.

Nat. Med. 6, 513-515

Ludwig, S., Pleschka, S., and Wolff, T. (1999).

A fatal relationship - Influenza virus interactions with the host cell.

Viral Immunol., 12, 175-196

Ludwig, S., Pleschka, S., Planz. O., and Wolff, T. (2003)

Influenza virus induced signalling cascades: targets for antiviral therapy.

Trends Mol. Med., 9, 46-52

Ludwig S., Pleschka S., Planz, O. and T. Wolff (2006).

Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells.

Cell. Microbiol. 8,375–386.

Ludwig, S. (2007)

Influenza viruses and MAP kinase cascades – Novel targets for antiviral therapy?

Signal Transduction 7, 81-88

Ludwig, S. (2007)

Exploited defense – how influenza virus takes advantage of antivral signaling responses

Future Virology 2, 91-100

Ludwig, S., and Planz, O. (2008)

Influenza viruses and the NF-κB signaling pathway – towards a novel concept of antiviral therapy.

Biol. Chem., 389, 1307-1132

Ludwig, S. (2008)

Highlight - viruses and signaling (Editorial)

Biol. Chem., 389, 1251

Ehrhardt, C and Ludwig, S. (2009)

A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway.

Cell. Microbiol. Epub ahead of print (Mar 20)

Ludwig, S.(2009)

Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy.

J. Antimicrob. Chemother.,Epub ahead of print (May 6)

Ludwig, S. and Wolff, T. (2009)

Influenza A virus TRIMs the type I interferon response.

Cell Host Microbe 5, 420-421

Ludwig, S. (2009)

Disruption of virus- host cell interactions and cell signaling pathways as an antiviral approach against influenza virus infections.

Infect. Disord. Drug Targets (accepted)

Wolff, T. and Ludwig, S. (2009)

Influenza Viruses control the vertebrate TypeΙ IFN system: Factors, Mechanisms and Consequences.

J Interferon Cytokine Res. (in revision)