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Zentrum für Molekularbiologie der Entzündung - ZMBE

Infektiologie

 

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Institut für Infektiologie - Ausgewählte Publikationen seit 2006


Cichon, C., Sabharwal, H., Rüter, C., and Schmidt, M.A. (2014)
MicroRNAs regulate tight junction proteins and modulate epithelial/endothelial barrier functions.
Tissue Barriers; in press

 

Höfling, S., Scharnert, J., Cromme, C., Bertrand, J., Pap, T., Schmidt, M. A., and Rüter, C. (2014)
Manipulation of pro-inflammatory cytokine production by the bacterial cell-penetrating effector protein YopM is independent of its interaction with host cell kinases RSK1 and PRK2.
Virulence; Virulence. 2014 May 5;5(6). [Epub ahead of print] PMID:24799669

 

Marathe, R., Meel, C., Schmidt, N. C., Dewenter, L., Kurre, R., Greune, L., Schmidt, M. A., Müller, M. J. I., Lipowsky, R., Maier, B., and Klumpp, S. (2014) Bacterial twitching motility: a stochastic tug-of-war with directional memory.
Nature Comm. 5:3759 | doi: 10.1038/ncomms4759

 

Rüter, C., Ruiz Silva, M., Lubos, M,-L., Scharnert, J., Grabowski, B., Poceva, M., von Tils, D., Flieger, A., Heesemann, J., Bliska, J. B., Schmidt, M. A. (2014)

Rabbit monoclonal antibodies directed at the T3SS effector protein YopM identify human pathogenic Yersinia isolates.

Int. J. Med. Microbiol.; 304, 444-451.

 

Bielaszewska, M., Schiller, R., Lammers, L., Bauwens, A., Fruth, A., Middendorf, B., Schmidt, M.A., Tarr, P.I., Dobrindt, U., Karch, H., and Mellmann, A (2014).

Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6.

EMBO Molecular Medicine; 6, 347-357

 

Toval, F., Köhler, C.D., Vogel, U., Wagenlehner, F., Mellmann, A., Fruth, A., Schmidt, M.A., Karch, H., Bielaszewska, M., Dobrindt, U. (2013)

Characterization of Escherichia coli isolates from hospital inpatients or outpatients with urinary tract infection.

J. Clin. Microbiol.; 52, 407-418

 

Rüter C, Hardwidge PR. (2013)

Drugs from Bugs": bacterial effector proteins as promising biological (immune-) therapeutics.

FEMS Microbiol Lett. 351, 126-132

 

Bielaszewska, M., Rüter, C., Kunsmann, L., Greune, L., Bauwens, A., Zhang, W., Kuczius, T., Kim, K. S., Schmidt, M. A., Karch, H. (2013)

Enterohemorrhagic Escherichia coli hemolysin employs outer membrane vesicles to target mitochondria and cause endothelial and epithelial apoptosis.

PLoS Pathog 9(12): e1003797. doi:10.1371/journal.ppat.1003797

 

Scharnert, J., Zeuschner, D., Greune, L., Lubos, M.-L., Schmidt, M. A., Rüter, C. (2013)

Autonomous translocation and intracellular trafficking of the cell-penetrating and immune-suppressive effector protein YopM.

Cell. Mol. Life Sci. 2013 Dec;70(24):4809-23.

 

Kouzel, I., Pohlentz, G., Strock, W., Hoffmann, P., Bielaszewska, M., Bauwens, A., Cichon, C., Schmidt, M. A., Mormann, M., Karch, H., and Müthing, J. (2013)

Association of Shiga toxin glycosphingolipid receptors with membrane microdomains of toxin-sensitive lymphoid and myeloid cells.

J. Lipid Res., 54, 692-710.

 

Blädel, I., Wagner, K., Beck, A., Schilling, J., Schmidt, M. A., and Heusipp, G. (2013)

The H-NS protein silences the pyp regulation network of Yersinia enterocolitica and is involved in controlling biofilm formation.

FEMS Microbiol. Lett., 340, 41-48.

 

Gao, X., Wang, X., Pham, T. H., Feuerbacher, L. A., Lubos, M.-L., Huang, M., Olsen, R., Mushegian, A., Slawson, C., Hardwidge, P. R. (2013)

A bacterial effector with glycosyltransferase activity targets GAPDH function in innate immunity.

Cell Host & Microbe, 13, 87-99.

 

von Tils, D., Blädel, I., Schmidt, M. A., Heusipp, G. (2012)

Type II secretion in Yersinia – a secretion system for pathogenicicy and environmental fitness.

Front. Cell. Inf. Microbio., doi: 10.3389/fcimb.2012.00160

 

Müthing, J., Meisen, I., Zhang, W., Bielaszewska, M., Mormann, M., Bauernfeind, R., Schmidt, M. A., Friedrich, A. W., and Karch, H. (2012)

Promiscuous Shiga toxin 2e and ist intimate relationship to Forssman.

Glycobiology, 22, 849-862.

 

Veltman, K., Hummel, S., Cichon, C., Sonnenborn, U., and Schmidt, M. A. (2012).

Modulation of epithelial barrier integrity by probiotic E. coli identifies microRNAs for tight junction maintenance.

Int. J. Biochem. Cell Biol., 44, 341-349.

 

Hummel, S., Veltman, K., Cichon, C., Sonnenborn, U., and Schmidt, M. A. (2012)

Differential targeting oft the E-cadherin/ß-Catenin complex by Gram-positive probiotic lactobacilli improves epithelial barrier function.

Appl. Environ. Microbiol., 78,1140-1147.


Wewer, C., Seibt, A., Greune, L., Schmidt, M. A., Galla, H.-J., Schwerk, C., Schroten, H., and Tenenbaum, T. (2011).

Transcellular and paracellular migration of neutrophil granulocytes through the blood-cerebrospinal-fluid barrier after infection with Streptococcus suis.

J. Neuroinflammation 8, 51 (http://www.jneuroinflammation.com/content/8/1/51)

 

Liebchen, A., Benz, I., Mellmann, A., Karch, H., Gomes, T. A.T., Yamamoto, D., Hernandes, R., Sampaio, J., Sampaio, S. C. F., Fruth, A., and Schmidt, M. A. (2011).
Characterization of Escherichia coli strains isolated from diarrhea patients in São Paulo: Identification of intermediate virulence factor profiles by multiplex PCR.
J. Clin. Microbiol. 49, 2274-2278.

 

Benz, I., and Schmidt, M. A. (2011).
Structure and functions of autotransporter proteins in microbial pathogens.
Int. J. Med. Microbiol., 301, 461-468.

 

Seidel, G., Böcker, K., Schulte, J., Wewer, C., Greune, L., Humberg, V., and Schmidt, M. A. (2011).
Permeabilization of cerebral endothelial barriers by pertussis toxin enhances the traversal of Escherichia coli K1, macrophages, and monocytes in vitro.
Int. J. Med. Microbiol. 301, 204-212.

 

Schmidt, M.A. (2010)

LEEways: tales of EPEC, ATEC, and EHEC.

Cell. Microbiol. 12(11), 1544-1552.

 

Hirschhausen, N., Schlesier, T., Schmidt, M.A., Götz, F., Peters, G., Heilmann, C. (2010)

A novel Staphylococcal internalization mechanism involves the major autolysin Atl and heat shock cognate protein Hsc70 as host cell receptor.

Cell. Microbiol. 12(12), 1746-1764.

 

Schilling, J., Wagner, K., Seekircher, S., Greune, L., Humberg, V., Schmidt, M. A., and Heusipp, G. (2010)

Transcriptional activation of the tad type IVb pilus operon by PypB in Yersinia enterocolitica.

J. Bacteriol. 192, 3809-3821.

 

Holz, C., Opitz, D., Greune, L., Kurre, R., Koomey, M., Schmidt, M. A., and Maier, B. (2010)

Multiple pilus motors cooperate for persistent bacterial movement in two dimensions.

Phys. Rev. Lett. 104, 178104

 

Benz, I., van Alen, T., Bolte, J., Wörmann, M. E., and Schmidt, M. A. (2010)

Modulation of transcription and characterization of the promotor organization of the autotransporter adhesin heptosyltransferase and the autotransporter adhesin AIDA-I.

Microbiology 156, 1155-1166.

 

Rüter, C., Buss, C., Scharnert, J., Heusipp, G., and Schmidt, M. A. (2010)

A newly identified bacterial cell-penetrating peptide that reduces the transcription of pro-inflammatory cytokines.

J. Cell Science 123, 2190-2198.

 

Shutinoski, B., Schmidt, M. A., Heusipp, G. (2010)

Transcriptional regulation of the Yts1 type II secretion system of Yersinia enterocolitica and identification of secretion substrates.

Mol. Microbiol. 75, 676-691.

 

Müller, D., Benz, I., Liebchen, A., Gallitz, I., Karch, H., Schmidt, M.A. (2009)

Comparative analysis of the locus of enterocyte effacement and ist flanking regions.

Infect. Immun. 77, 3501-3513.

 

Bielaszewska, M., Bauwens, A., Greune, L., Dobrindt, U., Geelen, J. M., Kim, K.-S., Schmidt, M. A., and Karch, H. (2009)

Vacuolisation of human microvascular endothelial cells by enterohemorrhagic Escherichia coli.

Thrombosis Haemostasis, 102, 1080-1092.

 

Rönnebäumer, K., Sander, G., Shutinoski, B., Schmidt, M. A., and Heusipp, G. (2009)

Controlled activation of the Cpx system is essential for growth of Yersinia enterocolitica.

FEMS Microbiol. Lett. 296, 274-281.

 

Yamamoto, D., Hernandes, R. T., Blanco, M., Greune, L., Schmidt, M. A. , Carneiro, S. M., Dahbi, G., Blanco, J. E., Mora, A., Blanco, J., and Gomes, T. A. T. (2009)

Invasiveness as a putative additional virulence mechanism of some atypical enteropathogenic Escherichia coli strains with different uncommon intimin types.

BMC Microbiology, 9, 146 doi:10.1186/1471-2180-9-146

 

Wagner, K., Schilling, J., Fälker, S., Schmidt, M. A. and Heusipp, G. (2009)

A regulatory network controls the expression of the in vivo expressed HreP protease of Yersinia enterocolitica.

J. Bacteriol. 191, 1666-1676.

 

Buss, C., Müller, D., Rüter, C., Heusipp, G., and Schmidt, M. A. (2009)

Identification and characterization of Ibe, a novel type III effector protein of A/E pathogens targeting human IQGAP1.

Cell. Microbiol.,11(4), 661-677. [COVER]

 

Distler, U., Souady, J., Hülsewig, M., Drmíc-Hofman, I., Haier, J., Friedrich, A. W., Karch, H., Senniger, N., Dreisewerd, K., Berkenkamp, S., Schmidt, M. A., Peter-Katalinic, J., and Müthing, J. (2009)

Shiga toxin receptor Gb3Cer/CD77: tumor-association and promising theraputic target in pancreas and colon cancer.

PLoS ONE 4(8):e6813

 

Gorris, H. H., Bade, S., Röckendorf, N., Albers, E., Schmidt, M. A. , Fránck, M., and Frey, A. (2009)

Rapid profiling of peptide stability in proteolytic environments.

Anal. Chem. 81, 1580-1586.

 

Distler, U., Souady, J., Hülsewig, M., Drmíc-Hofman, I., Haier, J., Denz, A., Grützman, R., Pilarsky, C., Senninger, N., Dreisewert, K., Berkenkamp, S., Schmidt, M. A., Peter-Katalinic, J., and Müthing, J. (2008)

Tumor-associated CD75s- and iso-CD75s-gangliosides are potential targets for adjuvant therapy in pancreatic cancer.

Mol. Canc. Ther. 7(8), 2464-2475.

 

Mellmann, A., Bielaszewska, M., Köck, R., Friedrich, A. W., Fruth, A., Middendorf, B., Harmsen, D., Schmidt, M. A., and Karch, H. (2008)

Analysis of a collection of hemolytic uremic syndrome associated enterohemorrhagic Escherichia coli.

Emerg. Infect. Dis. 14, 1287-1290.

 

Bielaszewska, M., Middendorf, B., Köck, R., Friedrich, A. W., Fruth, A., Karch, H., Schmidt, M. A. and Mellmann, A. (2008)

Shiga toxin-negative attaching and effacing Escherichia coli: Distinct clinical associations with bacterial phylogeny and virulence traits, and inferred in-host pathogen evolution.

Clin. Infect. Dis. 47, 208-217.

 

Müsken, A., Bielaszewska, M., Greune, L., Schweppe, C. H., Müthing, J., Schmidt, M. A., Karch, H., and Zhang, W. (2008)

Anaerobic conditions promote the expression of Sfp fimbriae and adherence of sorbitol-fermenting enterohemorrhagic Escherichia coli O157:NM to human intestinal epithelial cells.

Appl. Environ. Microbiol. 74(4),1087-1093.

 

Schweppe, C. H., Bielaszewska, M., Pohlentz, G., Friedrich, A. W., Büntemeyer, H., Schmidt, M. A., Kim, K.-S., Peter-Katalinic, J., Karch, H., and Müthing, J. (2008)

Glycosphingolipids in vascular endothelial cells: relationship of heterogeneity in Gb3Cer/CD77 receptor expression with differential Shiga toxin 1 cytotoxicity.

Glycoconjugate J. 25(4),291-304.

 

Li, C., Zhu, Y., Benz, I., Schmidt, M. A., Mulchandani, A., Chen, W., and Qiao, C. (2008)

Presentation of functional organophosphorus hydrolase fusions on the surface of Escherichia coli by the AIDA-I autotransporter pathway.

Biotechnol. Bioengineering 99, 485-490.

 

Mellmann, A., Lu, S., Karch, H., Xu, J.-G., Harmsen, D., Schmidt, M. A., and Bielaszewska M. (2008)

Recycling of Shiga toxin 2 genes in sorbitol-fermenting enterohemorrhagic Escherichia coli O157:NM.

Appl. Environ. Microbiol. 74(1), 67-72.

 

Buddenborg, C., Daudel, D., Liebrecht, S., Greune, L., Humberg, V., and Schmidt, M. A. (2008)

Tripartite vector system development for live oral immunization using a Gram-negative probiotic carrier.

Int. J. Med. Microbiol. 298,105-114.

 

Westphal, S., Lügering, A., von Wedel, J., von Eiff, C., Maaser, C., Spahn, T., Heusipp, G., Schmidt, M. A., Herbst, H., Williams, I., Domschke, W., and Kucharzik, T. (2007)

Resistance of CCR deficient mice to Yersinia enterocolitica infection – evidence of defective M cell formation in vivo.

Am. J. Pathol. 172(3), 671-680.

 

Fälker, S., Schilling, J., Schmidt, M. A., and Heusipp, G. (2007)

Overproduction of DNA adenine methyltransferase alters motility, invasion, and the lipopolysaccharide O-antigen composition of Yersinia enterocolitica.

Infect. Immun. 75, 4990-4997.

 

Pielage, F. J., Cichon, C., Greune, L., Hirashima, M., Kucharzik, T., and Schmidt, M. A. (2007)

Reversible differentiation of Caco-2 cells reveals galectin-9 as a surface marker molecule for human follicle-associated epithelia and M cell-like cells.

Int. J. Biochem. Cell Biol. 39, 1886-1901.

 

Bielaszewska, M., Sonntag, A.-K., Schmidt, M.A., and Karch, H. (2007)

Pressence of virulence and fitness gene modules of enterohemorrhagic Escherichia coli in atypical enteropathogenic Escherichia coli O26.

Microbes & Infection, 9, 891-897

 

Bielaszewska, M., Dobrindt, U., Gärtner, J., Gallitz, I., Hacker, J., Karch, H., Müller, D., Schubert, S., Schmidt, M.A., Sorsa, L.J., and Zdiarski, J. (2007)

Aspects of genome plasticity in pathogenic Escherichia coli.

Int. J. Med. Microbiol., 297, 625-639

 

Müller, D., Greune, L., Heusipp, G., Karch, H., Fruth, A., Tschäpe, H., and Schmidt, M.A. (2007)

Identification of unconventional intestinal pathogenic Escherichia coli expressing intermediate virulence factor profiles wit ha novel single stepp multiplex PCR.

Appl. Environ. Microbiol., 73, 3380-3390

 

Bielaszewska, M., Aldick, T., Zhang, W., Brockmeyer, J., Friedrich A.W, Kim, K.S., Schmidt, M.A., and Karch, H. (2007)

Shiga toxin-negative Escherichia coli O26:H11 and O26:NM strains from patients with hemolytic uremic syndrome: repertoire of virulence genes and interaction with human intestinal epithelial cells and endothelial cells.

Microbes & Infection, 9(3), 1-9.

 

Heusipp, G., Fälker, S., and Schmidt, M.A. (2007)

DNA adenine methylation and bacterial pathogenesis.

Intern. J. Med. Microbiol. 297,1-7.

 

Zyrek, A.A.  Cichon, C., Helms, S., Enders, C., Sonnenborn, U., and Schmidt, M.A. (2007)

Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 resulting in tight junction and epithelial barrier restoration involve ZO-2 and PKCz.

Cell Microbiol, 9, 804-816. (first published online 03. November 2006)

 

Kügler, S., Böcker, K., Heusipp, G., Greune, L., Kim, K.S. and Schmidt, M.A. (2007)

Pertussis toxin transiently affects barrier integrity, organelle organization, and transmigration of monocytes in a human brain microvascular endothelial cell barrier model.

Cell. Microbiol. 9, 619-632. (first published online 26. September 2006)

 

Boetel, T., Bade, S., Schmidt, M.A., and Frey, A. (2006)

Prion protein 90-231 contains a streptavidin-binding motif.

Biochem. Biophys. Res. Commun. 349, 296-302.

 

Fälker, S., Schmidt, M.A., and Heusipp, G. (2006)

Altered Ca2+ regulation of Yop secretion in Yersinia enterocolitica after DNA Adenine methyltransferase overproduction is mediated by ClpP-dependent degradation of LcrG.

J. Bacteriol. 188, 7072-7081.

 

Müller, D., Hagedorn, P., Brast, S., Heusipp, G., Bielaszewska, M., Friedrich, A.W., Karch, H., and Schmidt, M.A. (2006)

Rapid identification and differentiation of clinical isolates of enteropathogenic Escherichia coli (EPEC), atypical EPEC and Shiga toxin-producing Escherichia coli by single multiplex-PCR.

J. Clin. Microbiol., 44, 2626-2629.

 

Jain, S., van Ulsen, J.P., Benz, I., Schmidt, M.A., Fernandez, R., Tommassen, J. , and Goldberg, M.B. (2006)

Polar secretion of a family of large bacterial virulence proteins.

J. Bacteriol., 188, 4841-4850.

 

Karch, H., Friedrich, A.W., Gerber, A., Zimmerhackl, L.B., Schmidt, M.A. and Bielaszwska, M. (2006)

New aspects in the pathogenesis of enteropathic hemolytic uremic syndrome.

Sem. Thromb. Hemostas. 32,105-112.

 

Heusipp, G., Spekker, K., Brast, S., Fälker, S., and Schmidt, M.A. (2006)

YopM of Yersinia enterocolitica specifically interacts with a1-antitrypsin without affecting the anti-protease activity.

Microbiology 152, 1327-1335.

 

Michgehl, S., Heusipp, G., Greune, L., Rüter, C., and Schmidt, M.A. (2006)

Esp-independent functional integration of the translocated intimin receptor (Tir) of enteropathogenic Escherichia coli (EPEC) into host cell membranes.

Cell. Microbiol. 8, 625-633.